Article
A human modifier of methylation for class I HLA genes (MEMO-1) maps to chromosomal bands 1p35-36.1.
Human molecular genetics - 1 Mar 1996
Cheng N C, Chan A J, Beitsma M M, Speleman F, Westerveld A, Versteeg R
Abstract excerpt
Class I HLA genes are expressed in almost all tissues, but expression is low or undetectable in many neuroblastomas. We analysed class I HLA methylation in normal tissues and in 28 neuroectodermal tumour cell lines. HLA-C is hypermethylated in normal adult tissues and 13 cell lines, while 15 cell lines show the hypomethylated phenotype. Hypomethylation of HLA-C strongly correlates with hemizygous deletion of a 9...
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