Article
The reductive conversion of the carcinogen chromium (VI) and its role in the formation of DNA lesions.
Annals of clinical and laboratory science - 1 Jan 2000
Kortenkamp A, Casadevall M, Da Cruz Fresco P
Abstract excerpt
The potential of Cr(VI), in combination with glutathione (GSH) or ascorbate (AsA) to induce apurinic/apyrimidinic sites (AP-sites) and single strand breaks (SSB) in isolated deoxyribonucleic acid (DNA) was investigated. The observation that both lesions were formed with equal probability and followed a similar time course suggests that they might arise from attack of a reactive species at C4' of the DNA sugar...
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