Article
Comparative analysis of the genetic associations of HLA-DR3 and tumour necrosis factor alpha with human IDDM.
Diabetologia - 1 May 1994
Cox A, Gonzalez A M, Wilson A G, Wilson R M, Ward J D, Artlett C M, Welsh K, Duff G W
Abstract excerpt
Insulin-dependent diabetes mellitus (IDDM) is associated with class II molecules of the MHC on chromosome 6, in particular HLA-DR and -DQ alleles, but a pathogenic role for TNF-alpha in the class III region of the MHC has also been implied. We therefore tested whether there was any independent as...
Topics
- Adult
- Age of Onset
- Alleles
- Base Sequence
- DNA Primers
- Diabetes Mellitus, Type 1
- Gene Frequency
- Genotype
- HLA-DR1 Antigen
- HLA-DR3 Antigen
- Haplotypes
- Histocompatibility Testing
- Humans
- Molecular Sequence Data
- Odds Ratio
- Polymerase Chain Reaction
- Reference Values
- Tumor Necrosis Factor-alpha