Article
Comparative analysis of the genetic associations of HLA-DR3 and tumour necrosis factor alpha with human IDDM.
Diabetologia - 1 May 1994
Cox A, Gonzalez A M, Wilson A G, Wilson R M, Ward J D, Artlett C M, Welsh K, Duff G W
Abstract excerpt
Insulin-dependent diabetes mellitus (IDDM) is associated with class II molecules of the MHC on chromosome 6, in particular HLA-DR and -DQ alleles, but a pathogenic role for TNF-alpha in the class III region of the MHC has also been implied. We therefore tested whether there was any independent association between a biallelic TNF polymorphism and IDDM. The TNF2 allele was present in 61 of 114 (54%) IDDM patients...
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