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Article

Tissue-specific inactivation of p53 tumor suppression in the mouse.

Genes & development - 1 Apr 1996

Bowman T, Symonds H, Gu L, Yin C, Oren M, Van Dyke T

Abstract excerpt

The p53 gene is the most frequent target of structural and functional genetic mutations in human cancer. Thus, considerable effort has been devoted to mapping the functional domains of p53 with regard to their impact on tumorigenesis in vivo. Studies have shown that the carboxy-terminal domain of p53 is sufficient for transformation in vitro. To determine whether a transdominant-negative p53 protein could be used...

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Source

Identifiers

PMID: 8846919
DOI: 10.1101/gad.10.7.826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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