Article
p53-dependent apoptosis suppresses tumor growth and progression in vivo.
Cell - 26 Aug 1994
Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T, Van Dyke T
Abstract excerpt
To determine the contribution of p53 loss to tumor progression, we have induced abnormal proliferation in the brain choroid plexus epithelium of transgenic mice using a SV40 T antigen fragment that perturbs pRB family function but does not affect p53 function. Tumors induced by this mutant develo...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Apoptosis
- Base Sequence
- Cell Transformation, Neoplastic
- Choroid Plexus
- Choroid Plexus Neoplasms
- Crosses, Genetic
- Epithelium
- Mice
- Mice, Transgenic
- Models, Biological
- Molecular Sequence Data
- Mutation
- Tumor Suppressor Protein p53