Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53-dependent apoptosis suppresses tumor growth and progression in vivo.

Cell - 26 Aug 1994

Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T, Van Dyke T

Abstract excerpt

To determine the contribution of p53 loss to tumor progression, we have induced abnormal proliferation in the brain choroid plexus epithelium of transgenic mice using a SV40 T antigen fragment that perturbs pRB family function but does not affect p53 function. Tumors induced by this mutant develop slowly compared with those induced by wild-type T antigen. Suppressed tumor growth is directly attributable to p53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Transformation, Neoplastic
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Models, Biological

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 8069917
DOI: 10.1016/0092-8674(94)90534-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53-dependent apoptosis suppresses tumor growth and progression in vivo.PMID 8069917Read ↗

p53-independent apoptosis during mammary tumor progression in C3(1)/SV40 large T antigen transgenic mice: suppression of apoptosis during the transition from preneoplasia to carcinoma.Semantic proximity Read ↗

Tissue-specific inactivation of p53 tumor suppression in the mouse.Semantic proximity Read ↗

pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent EpitheliaSemantic proximity Read ↗

Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression.Semantic proximity Read ↗

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.Semantic proximity Read ↗

Increased tumor cell proliferation in murine tumors with decreasing dosage of wild-type p53.Semantic proximity Read ↗

Increased oncogenicity of subclones of SV40 large T-induced neuroectodermal tumor cell lines after loss of large T expression and concomitant mutation in p53.Semantic proximity Read ↗

Direct evidence of cellular transformation by prion-like p53 amyloid infection.Semantic proximity Read ↗

Dissecting p53 tumor suppressor functions in vivo.Semantic proximity Read ↗

Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53.Semantic proximity Read ↗

Autonomous growth and hepatocarcinogenesis in transgenic mice expressing the p53 family inhibitor DNp73Semantic proximity Read ↗

Effects of genetic background on tumorigenesis in p53-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.