Article
Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis.
Human immunology - 1 Jan 2007
Sainz Juan, Pérez Eva, Hassan Laila, Moratalla Antonio, Romero Antonio, Collado María Dolores, Jurado Manuel
Abstract excerpt
Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) are pivotal mediators of inflammatory responses in fungal infection diseases. We hypothesized that polymorphisms in genes of these cytokines or their receptors might increase the susceptibility of hematologic patients to develop invasive pulmonary aspergillosis (IPA). One hundred two hematologic patients and 124 age-matched controls were...
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