Article
Differential expression of dystrophin isoforms in strains of mdx mice with different mutations.
Human molecular genetics - 1 Aug 1996
Im W B, Phelps S F, Copen E H, Adams E G, Slightom J L, Chamberlain J S
Abstract excerpt
Mutations in the dystrophin gene are responsible for Duchenne and Becker muscular dystrophy (DMD/BMD). Studies of dystrophin expression and function have benefited from use of the mdx mouse, an animal model for DMD/BMD. Here we characterized mutations in three additional strains of mdx mice, the mdx2cv, mdx4cv and mdx5cv alleles. The mutation in the mdx2cv mouse was found to be a single base change in the splice...
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