Article
Differential expression of dystrophin isoforms in strains of mdx mice with different mutations.
Human molecular genetics - 1 Aug 1996
Im W B, Phelps S F, Copen E H, Adams E G, Slightom J L, Chamberlain J S
Abstract excerpt
Mutations in the dystrophin gene are responsible for Duchenne and Becker muscular dystrophy (DMD/BMD). Studies of dystrophin expression and function have benefited from use of the mdx mouse, an animal model for DMD/BMD. Here we characterized mutations in three additional strains of mdx mice, the...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA, Complementary
- Dystrophin
- Frameshift Mutation
- Gene Expression
- Mice
- Mice, Inbred mdx
- Molecular Sequence Data
- Muscular Dystrophy, Animal
- Mutation
- Point Mutation
- Polymerase Chain Reaction
- RNA Splicing