Article
New mdx mutation disrupts expression of muscle and nonmuscle isoforms of dystrophin.
Nature genetics - 1 May 1993
Cox G A, Phelps S F, Chapman V M, Chamberlain J S
Abstract excerpt
The dystrophin gene encodes several tissue-specific protein isoforms that are generated by alternative splicing and by transcription from at least three separate promoters. We have characterized the mutation in a new strain of mdx mice that results in aberrant splicing of both the 14 and 4.8 kilo...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Mutational Analysis
- Dystrophin
- Exons
- Female
- Gene Expression Regulation
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Molecular Sequence Data