Article
The influence of muscle type and dystrophin deficiency on murine expression profiles.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2005
Haslett Judith N, Kang Peter B, Han Mei, Kho Alvin T, Sanoudou Despina, Volinski Jay M, Beggs Alan H, Kohane Isaac S, Kunkel Louis M
Abstract excerpt
The phenotypic differences among Duchenne muscular dystrophy patients, mdx mice, and mdx(5cv) mice suggest that despite the common etiology of dystrophin deficiency, secondary mechanisms have a substantial influence on phenotypic severity. The differential response of various skeletal muscles to dystrophin deficiency supports this hypothesis. To explore these differences, gene expression profiles were generated...
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