Article
A transgene insertion at perinatal lethality (ple) is associated with abnormalities of the cortex.
Brain research - 15 Jul 1996
Beier D R, Dushkin H, Stone L V, Sherman G F
Abstract excerpt
In an inbred genetic background, mice homozygous for a transgene insertion at perinatal lethality (ple) were found to be significantly smaller than their heterozygous or wild-type siblings at birth, and rarely survived for more than 48 h. Homozygous progeny of ple mice obtained from a cross with a different strain were viable, but were still not obtained in the expected numbers, demonstrating some deleterious...
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