The hydrogenase gene cluster of Rhizobium leguminosarum bv. viciae contains an additional gene (hypX), which encodes a protein with sequence similarity to the N10-formyltetrahydrofolate-dependent enzyme family and is required for nickel-dependent hydrogenase processing and activity.

doi:10.1007/BF02173769

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Article

The hydrogenase gene cluster of Rhizobium leguminosarum bv. viciae contains an additional gene (hypX), which encodes a protein with sequence similarity to the N10-formyltetrahydrofolate-dependent enzyme family and is required for nickel-dependent hydrogenase processing and activity.

Molecular & general genetics : MGG - 13 Sept 1996

Rey L, Fernández D, Brito B, Hernando Y, Palacios J M, Imperial J, Ruiz-Argüeso T

Abstract excerpt

Plasmid pAL618 contains the genetic determinants for H2 uptake (hup) from Rhizobium leguminosarum bv. viciae, including a cluster of 17 genes named hupSLCDEFGHIJK-hypABFCDE. A 1.7-kb segment of insert DNA located downstream of hypE has now been sequenced, thus completing the sequence of the 20441...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Carrier Proteins
Cloning, Molecular
DNA, Bacterial
Escherichia coli
Escherichia coli Proteins
GTP-Binding Proteins
Hydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Multigene Family

Mutation

Nickel

Phenotype

Promoter Regions, Genetic

Protein Processing, Post-Translational

Rhizobium leguminosarum

Source

Open in PubMed

Identifiers

PMID: 8842143
DOI: 10.1007/BF02173769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8842143-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The hydrogenase gene cluster of Rhizobium leguminosarum bv. viciae contains an additional gene (hypX), which encodes a protein with sequence similarity to the N10-formyltetrahydrofolate-dependent enzyme family and is required for nickel-dependent hydrogenase processing and activity.PMID 8842143Read ↗

The sequences of hypF, hypC and hypD complete the hyp gene cluster required for hydrogenase activity in Bradyrhizobium japonicum.Semantic proximity Read ↗

Genetic organization of the hydrogen uptake (hup) cluster from Rhizobium leguminosarum.Semantic proximity Read ↗

Nucleotide sequence and characterization of four additional genes of the hydrogenase structural operon from Rhizobium leguminosarum bv. viciae.Semantic proximity Read ↗

Construction and properties of a triprotein containing the high-affinity nickel transporter of Alcaligenes eutrophus.Semantic proximity Read ↗

hoxX (hypX) is a functional member of the Alcaligenes eutrophus hyp gene cluster.Semantic proximity Read ↗

Cloning, nucleotide sequence, and heterologous expression of a high-affinity nickel transport gene from Alcaligenes eutrophus.Semantic proximity Read ↗

The HypB protein from Bradyrhizobium japonicum can store nickel and is required for the nickel-dependent transcriptional regulation of hydrogenase.Semantic proximity Read ↗

Diversity and evolution of hydrogenase systems in rhizobia.Semantic proximity Read ↗

hyp gene products in Alcaligenes eutrophus are part of a hydrogenase-maturation system.Semantic proximity Read ↗

Identification of a locus within the hydrogenase gene cluster involved in intracellular nickel metabolism in Bradyrhizobium japonicum.Semantic proximity Read ↗

Sequences and characterization of hupU and hupV genes of Bradyrhizobium japonicum encoding a possible nickel-sensing complex involved in hydrogenase expression.Semantic proximity Read ↗

Differential expression of hydrogen uptake (hup) genes in vegetative and symbiotic cells of Rhizobium leguminosarum.Semantic proximity Read ↗

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