Some repair-deficient mutants of Dictyostelium discoideum display enhanced susceptibilities to bleomycin.

doi:10.1128/AAC.40.2.464

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Article

Some repair-deficient mutants of Dictyostelium discoideum display enhanced susceptibilities to bleomycin.

Antimicrobial agents and chemotherapy - 1 Feb 1996

Deering R A, Guyer R B, Stevens L, Watson-Thais T E

Abstract excerpt

Dictyostelium discoideum, a soil eukaryote, is highly resistant to DNA-damaging agents; repair mutants are more susceptible. Susceptibility to bleomycin, produced by Streptomyces verticillus, is greater for mutants which are susceptible to other agents than for resistant strains. The high potenti...

Topics

Animals
Anti-Bacterial Agents
Bleomycin
DNA Repair
DNA, Bacterial
Dictyostelium
Dose-Response Relationship, Drug
Drug Resistance, Microbial
Mutation

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