Article
Some repair-deficient mutants of Dictyostelium discoideum display enhanced susceptibilities to bleomycin.
Antimicrobial agents and chemotherapy - 1 Feb 1996
Deering R A, Guyer R B, Stevens L, Watson-Thais T E
Abstract excerpt
Dictyostelium discoideum, a soil eukaryote, is highly resistant to DNA-damaging agents; repair mutants are more susceptible. Susceptibility to bleomycin, produced by Streptomyces verticillus, is greater for mutants which are susceptible to other agents than for resistant strains. The high potential for DNA repair may result from the need to cope with chemicals produced by other soil microorganisms.
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