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Article

Xpf and not the Fanconi anaemia proteins or Rev3 accounts for the extreme resistance to cisplatin in Dictyostelium discoideum.

PLoS genetics - 1 Sept 2009

Zhang Xiao-Yin, Langenick Judith, Traynor David, Babu M Madan, Kay Rob R, Patel Ketan J

Abstract excerpt

Organisms like Dictyostelium discoideum, often referred to as DNA damage "extremophiles", can survive exposure to extremely high doses of radiation and DNA crosslinking agents. These agents form highly toxic DNA crosslinks that cause extensive DNA damage. However, little is known about how Dictyostelium and the other "extremophiles" can tolerate and repair such large numbers of DNA crosslinks. Here we describe a...

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PMID: 19763158
DOI: 10.1371/journal.pgen.1000645
PMCID: PMC2730050

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