Article
The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis.
The Journal of infectious diseases - 15 Jun 2013
Jarvis Joseph N, Casazza Joseph P, Stone Hunter H, Meintjes Graeme, Lawn Stephen D, Levitz Stuart M, Harrison Thomas S, Koup Richard A
Abstract excerpt
BACKGROUND: Correlates of immune protection in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis are poorly defined. A clearer understanding of these immune responses is essential to inform rational development of immunotherapies. METHODS: Cryptococcal-specific peripheral CD4(+) T-cell responses were measured in 44 patients with HIV-associated cryptococcal meningitis at baseline...
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