Article
A tyrosyl-tRNA synthetase suppresses structural defects in the two major helical domains of the group I intron catalytic core.
Journal of molecular biology - 20 Sept 1996
Myers C A, Wallweber G J, Rennard R, Kemel Y, Caprara M G, Mohr G, Lambowitz A M
Abstract excerpt
The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase, the CYT-18 protein, functions in splicing group I introns by promoting the formation of the catalytically active structure of the intron RNA. The group I intron catalytic core is thought to consist of two extended helical domains, one f...
Topics
- Bacteriophage T4
- Base Sequence
- Chromosome Mapping
- Escherichia coli
- Introns
- Kinetics
- Mitochondria
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Neurospora crassa
- Nucleic Acid Conformation
- Phenotype
- RNA Splicing
- RNA, Viral
- Tyrosine-tRNA Ligase