Article
The Neurospora crassa CYT-18 protein C-terminal RNA-binding domain helps stabilize interdomain tertiary interactions in group I introns.
RNA (New York, N.Y.) - 1 Apr 2004
Chen Xin, Mohr Georg, Lambowitz Alan M
Abstract excerpt
The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) promotes the splicing of group I introns by stabilizing the catalytically active RNA structure. To accomplish this, CYT-18 recognizes conserved structural features of group I intron RNAs using regions of the N-terminal nucleotide-binding fold, intermediate alpha-helical, and C-terminal RNA-binding domains that also function in binding...
Topics
- Introns
- Mitochondria
- Mutation
- Neurospora crassa
- Nucleic Acid Conformation
- Protein Structure, Tertiary
- Saccharomyces cerevisiae
- Sequence Analysis, Protein
- Tyrosine-tRNA Ligase