Neurovirulence for rats of the JHMV variants escaped from neutralization with the S1-specific monoclonal antibodies.

doi:10.1007/978-1-4615-1899-0_31

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Article

Neurovirulence for rats of the JHMV variants escaped from neutralization with the S1-specific monoclonal antibodies.

Advances in experimental medicine and biology - 1 Jan 1995

Taguchi F, Suzuki H, Takahashi H, Kubo H

Abstract excerpt

We have studied the neurovirulence for rats of the MAb-resistant variants isolated from a highly neurovirulent JHMV, cl-2. The variants, MM6 and MM13, with point mutation located within the N terminal 100 amino acids (aa) of the S1 protein showed no alteration in neurovirulence in comparison with...

Topics

Animals
Antibodies, Monoclonal
Antibody Specificity
Coronavirus Infections
Genetic Variation
Membrane Glycoproteins
Mice
Murine hepatitis virus
Neutralization Tests
Point Mutation
Rats
Sequence Deletion
Species Specificity
Spike Glycoprotein, Coronavirus
Viral Envelope Proteins
Virulence

Source

Open in PubMed

Identifiers

PMID: 8830478
DOI: 10.1007/978-1-4615-1899-0_31

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8830478-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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