Article
Neurovirulence for rats of the JHMV variants escaped from neutralization with the S1-specific monoclonal antibodies.
Advances in experimental medicine and biology - 1 Jan 1995
Taguchi F, Suzuki H, Takahashi H, Kubo H
Abstract excerpt
We have studied the neurovirulence for rats of the MAb-resistant variants isolated from a highly neurovirulent JHMV, cl-2. The variants, MM6 and MM13, with point mutation located within the N terminal 100 amino acids (aa) of the S1 protein showed no alteration in neurovirulence in comparison with cl-2, showing high neurovirulence. The variants, MM65 and MM85, with a deletion composed of about 150 aa located in...
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