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Article

Neurovirulence in mice of soluble receptor-resistant (srr) mutants of mouse hepatitis virus: intensive apoptosis caused by less virulent srr mutant.

Archives of virology - 1 Jan 2001

Matsuyama S, Watanabe R, Taguchi F

Abstract excerpt

Three soluble receptor-resistant (srr) mutants, srr7, srr11 and srr18, derived from a highly neurotropic mouse hepatitis virus (MHV) JHMV have a single amino acid mutation in the spike (S) protein. We examined using ICR mice whether the amino acids mutated in the mutants were involved in the neurovirulence. Srr7 showed apparently reduced neurovirulence relative to the wild-type (wt) JHMV in terms of the LD50 and...

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Share to Coronavirus Infections
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred ICR

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Share to Spike Glycoprotein, Coronavirus

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Source

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Identifiers

PMID: 11699952
DOI: 10.1007/s007050170053
PMCID: PMC7086838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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