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Article

Gene targeting in kidney development.

Medical and pediatric oncology - 1 Nov 1996

Kreidberg J A

Abstract excerpt

Cancer and development are conceptually related because tumor formation in many cases results from the aberrant expression of a developmental program. This is certainly true of Wilms' tumors, which display a range of phenotypes resembling various stages of kidney development. WT1 has been identif...

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Identifiers

PMID: 8827072
DOI: 10.1002/(SICI)1096-911X(199611)27:5<445::AID-MPO10>3.0.CO;2-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8827072-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene targeting in kidney development.PMID 8827072Read ↗

WT1 and kidney progenitor cellsSemantic proximity Read ↗

WT-1 is required for early kidney development.Semantic proximity Read ↗

Multiple roles for the Wilms' tumour suppressor gene, WT1 in genitourinary development.Semantic proximity Read ↗

Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development.Semantic proximity Read ↗

Wilms' tumor gene 1: lessons from the interface between kidney development and cancer.Semantic proximity Read ↗

Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice.Semantic proximity Read ↗

Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiationSemantic proximity Read ↗

Exploring the Multifaceted Role of WT1 in Kidney Development and DiseaseSemantic proximity Read ↗

The tumor suppressor WT1 drives progenitor cell progression and epithelialization to prevent Wilms tumorigenesis in human kidney organoidsSemantic proximity Read ↗

Towards an understanding of kidney diseases associated with WT1 mutations.Semantic proximity Read ↗

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressorSemantic proximity Read ↗

Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylationSemantic proximity Read ↗

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