Variation of phenotype in patients with glucocorticoid remediable aldosteronism.

doi:10.1136/jmg.33.1.25

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Article

Variation of phenotype in patients with glucocorticoid remediable aldosteronism.

Journal of medical genetics - 1 Jan 1996

Gates L J, MacConnachie A A, Lifton R P, Haites N E, Benjamin N

Abstract excerpt

Glucocorticoid remediable aldosteronism (GRA), an autosomal dominant cause of primary aldosteronism, has been described as resulting in severe hypertension with premature death from stroke. We describe two new large pedigrees which include subjects who have the abnormal chimaeric gene strongly li...

Topics

Adult
Cytochrome P-450 CYP11B2
Female
Genetic Variation
Glucocorticoids
Humans
Hyperaldosteronism
Male
Middle Aged
Pedigree
Phenotype
Steroid 11-beta-Hydroxylase

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