Article
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.
Nature genetics - 1 Sept 1992
Lifton R P, Dluhy R G, Powers M, Rich G M, Gutkin M, Fallo F, Gill J R, Feld L, Ganguly A, Laidlaw J C
Abstract excerpt
Patients with glucocorticoid-remediable aldosteronism (GRA) from 12 kindreds possess chimaeric gene duplications arising from unequal crossing-over, fusing regulatory sequences of steroid 11 beta-hydroxylase to coding sequences of aldosterone synthase. These chimaeric genes are specific for GRA and explain the biochemistry, physiology and genetics of this form of hypertension. Sites of crossing over range from...
Topics
- Alleles
- Base Sequence
- Chimera
- Crossing Over, Genetic
- Cytochrome P-450 CYP11B2
- Cytochrome P-450 Enzyme System
- DNA
- Female
- Gene Expression
- Haplotypes
- Humans