Article
Glucocorticoid-remediable aldosteronism (GRA): diagnosis, variability of phenotype and regulation of potassium homeostasis.
Steroids - 1 Jan 1995
Dluhy R G, Lifton R P
Abstract excerpt
Glucocorticoid-remediable aldosteronism (GRA) is a hereditary cause of human hypertension in which aldosterone secretion is regulated by adrenocorticotropin (ACTH). A genetic mutation which causes GRA has recently been identified in our laboratory, a hybrid or chimeric gene fusing nucleotide sequences of the 11 beta-hydroxylase and aldosterone synthase genes. The finding that these chimeric gene duplications are...
Topics
- Blood Pressure
- Glucocorticoids
- Homeostasis
- Humans
- Hyperaldosteronism
- Phenotype
- Potassium
- Prevalence