Article
Clinical, biochemical and genetic features of five extended kindred's with glucocorticoid-suppressible hyperaldosteronism.
Endocrine research - 1 Jan 2000
Jamieson A, Slutsker L, Inglis G, Campbell M, Fraser R, White P, Connell J
Abstract excerpt
Glucocorticoid-suppressible hyperaldosteronism (GSH) is an uncommon form of dominantly inherited hypertension caused by the inheritence of a chimaeric 11 beta-hydroxylase/aldosterone synthase gene. Affected individuals appear to have an increased risk of premature morbidity and mortality from str...
Topics
- Chimera
- Cytochrome P-450 CYP11B2
- Cytochrome P-450 Enzyme System
- Depression, Chemical
- Dexamethasone
- Genes, Dominant
- Genotype
- Hyperaldosteronism
- Northern Ireland
- Phenotype
- Scotland
- Steroid 11-beta-Hydroxylase