Article
Glucocorticoid-remediable aldosteronism.
Endocrinology and metabolism clinics of North America - 1 Jun 1994
Dluhy R G, Lifton R P
Abstract excerpt
Glucocorticoid-remediable aldosteronism (GRA) is an autosomal-dominant form of human hypertension. In GRA in which aldosterone secretion is positively and solely regulated by ACTH, glucocorticoid administration relieves this mineralocorticoid excess syndrome. Recent studies demonstrate that GRA is caused by a gene duplication fusing regulatory sequences of the steroid 11 beta-hydroxylase gene to the coding...
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