Article
DNA sequence analysis of the major breakpoint cluster region of the BCR gene rearranged in Philadelphia-positive human leukemias.
Oncogene - 1 Jun 1993
Sowerby S J, Kennedy M A, Fitzgerald P H, Morris C M
Abstract excerpt
We sought sequence characteristics that might explain the apparent high recombination frequency of the 5-kb BglII segment containing M-bcr exons 1, 2 and 3, and the intron to exon 4. An Alu sequence (subfamily Sx), in 5'-->3' orientation, lay in the middle of a 3-kb region that contains the great...
Topics
- Base Sequence
- Chromosomes, Human, Pair 22
- DNA, Neoplasm
- DNA, Satellite
- Exons
- Gene Rearrangement
- Genetic Variation
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Molecular Sequence Data
- Oncogene Proteins
- Oncogenes
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcr
- Recombination, Genetic
- Repetitive Sequences, Nucleic Acid
- Restriction Mapping