Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stress kinase signaling in cancer: fact or fiction?

Cancer letters - 10 Jan 2005

Rennefahrt Ulrike, Janakiraman Manickam, Ollinger Robert, Troppmair Jakob

Abstract excerpt

Cancer results from genetic alterations in intracellular signaling pathways, which normally orchestrate the execution of developmental programs and the organismic response to extrinsic factors. Mutations in upstream activators and components of the cytoplasmic (Ras-Raf MEK-ERK) cascade frequently occur in tumors. In vitro and in vivo studies have shown that isolated activation of this pathway is both, necessary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cell Transformation, Neoplastic
Share to Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Signal Transduction

Source

Identifiers

PMID: 15596290
DOI: 10.1016/j.canlet.2004.08.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stress kinase signaling in cancer: fact or fiction?PMID 15596290Read ↗

Mitogen-activated protein kinase signal transduction in solid tumors.Semantic proximity Read ↗

Extrinsic and Cell-Intrinsic Stress in the Immune Tumor Micro-EnvironmentSemantic proximity Read ↗

Signal transduction in cancer.Semantic proximity Read ↗

Role of stress in the pathogenesis of cancer (Review)Semantic proximity Read ↗

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and SensitivitySemantic proximity Read ↗

Oncogenic signaling.Semantic proximity Read ↗

Key signal transduction pathways and crosstalk in cancer: Biological and therapeutic opportunitiesSemantic proximity Read ↗

A Comprehensive Review on MAPK: A Promising Therapeutic Target in CancerSemantic proximity Read ↗

Protein Kinases, Their Function and Implication in Cancer and Other DiseasesSemantic proximity Read ↗

The p38 Pathway: From Biology to Cancer TherapySemantic proximity Read ↗

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overviewSemantic proximity Read ↗

Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease statesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.