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Article

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes.

Molecular and cellular biology - 1 Oct 1996

Danska J S, Holland D P, Mariathasan S, Williams K M, Guidos C J

Abstract excerpt

The scid gene product has been identified as the 460-kDa catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs p460), a member of the phosphatidylinositol 3-kinase family. DNA-PK activity is undetectable in scid cells, but the molecular basis for this defect has not been identified. Here we report that expression of p460 in scid lymphocyte precursors is detectable but is reduced at least 10-fold...

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Identifiers

PMID: 8816463
DOI: 10.1128/MCB.16.10.5507
PMCID: PMC231550

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