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Article

DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia.

Gene - 23 Jan 2002

Ding Qi, Bramble Lori, Yuzbasiyan-Gurkan Vilma, Bell Thomas, Meek Katheryn

Abstract excerpt

Previously, spontaneous genetic immunodeficiencies in mice, Arabian foals, and recently in Jack Russell terriers have been ascribed to defects in DNA-PKcs (catalytic subunit of the DNA dependent protein kinase) expression. In severe combined immunodeficiency (SCID) foals, a 5 bp deletion at codon 9480 results in a frameshift and a 967 amino acid deletion from the C terminus (including the entire PI3 kinase...

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Identifiers

PMID: 11867233
DOI: 10.1016/s0378-1119(01)00880-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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