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Article

Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.

Molecular and cellular biology - 1 Oct 1996

Barr M M, Tu H, Van Aelst L, Wigler M

Abstract excerpt

A conserved MAP kinase cascade is central to signal transduction in both simple and complex eukaryotes. In the yeast Schizosaccharomyces pombe, Byr2, a homolog of mammalian MAPK/ERK kinase kinase and Saccharomyces cerevisiae STE11, is required for pheromone-induced sexual differentiation. A screen for S. pombe proteins that interact with Byr2 in a two-hybrid system led to the isolation of Ste4, a protein that is...

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Identifiers

PMID: 8816472
DOI: 10.1128/MCB.16.10.5597
PMCID: PMC231559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.PMID 8816472Read ↗

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.Semantic proximity Read ↗

Functional analysis of domains in the Byr2 kinase.Semantic proximity Read ↗

Mutational analyses of the interacting domains of Schizosaccharomyces pombe Byr2 with 14-3-3s.Semantic proximity Read ↗

Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction.Semantic proximity Read ↗

New Features Surrounding the Cdc42-Ste20 Module that Regulates MAP Kinase Signaling in YeastSemantic proximity Read ↗

Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes.Semantic proximity Read ↗

Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe.Semantic proximity Read ↗

Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction.Semantic proximity Read ↗

Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p.Semantic proximity Read ↗

The Byr2 kinase translocates to the plasma membrane in a Ras1-dependent manner.Semantic proximity Read ↗

Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.Semantic proximity Read ↗

Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase.Semantic proximity Read ↗

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