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Article

Mutational analyses of the interacting domains of Schizosaccharomyces pombe Byr2 with 14-3-3s.

Current genetics - 24 Jun 2024

Kobayashi-Ooka Yasuyo, Ozoe Fumiyo, Kawamukai Makoto

Abstract excerpt

The Byr2 kinase of fission yeast Schizosaccharomyces pombe is recruited to the membrane with the assistance of Ras1. Byr2 is also negatively regulated by 14-3-3 proteins encoded by rad24 and rad25. We conducted domain and mutational analysis of Byr2 to determine which region is critical for its binding to 14-3-3 proteins. Rad24 and Rad25 bound to both the Ras interaction domain in the N-terminus and to the...

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Source

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Identifiers

PMID: 38913087
DOI: 10.1007/s00294-024-01293-7
PMCID: PMC11196315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analyses of the interacting domains of Schizosaccharomyces pombe Byr2 with 14-3-3s.PMID 38913087Read ↗

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.Semantic proximity Read ↗

Functional analysis of domains in the Byr2 kinase.Semantic proximity Read ↗

Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.Semantic proximity Read ↗

The Byr2 kinase translocates to the plasma membrane in a Ras1-dependent manner.Semantic proximity Read ↗

Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe.Semantic proximity Read ↗

Regions of Byr4, a regulator of septation in fission yeast, that bind Spg1 or Cdc16 and form a two-component GTPase-activating protein with Cdc16.Semantic proximity Read ↗

Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast.Semantic proximity Read ↗

Functional characterization of the fission yeast Start-specific transcription factor Res2.Semantic proximity Read ↗

Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase.Semantic proximity Read ↗

Byr4 localizes to spindle-pole bodies in a cell cycle-regulated manner to control Cdc7 localization and septation in fission yeast.Semantic proximity Read ↗

Physical interaction between recombinational proteins Rhp51 and Rad22 in Schizosaccharomyces pombe.Semantic proximity Read ↗

Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes.Semantic proximity Read ↗

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