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Article

The magnitude of the backbone conformational entropy change in protein folding.

Proteins - 1 Jun 1996

D'Aquino J A, Gómez J, Hilser V J, Lee K H, Amzel L M, Freire E

Abstract excerpt

The magnitude of the conformational entropy change experienced by the peptide backbone upon protein folding was investigated experimentally and by computational analysis. Experimentally, two different pairs of mutants of a 33 amino acid peptide corresponding to the leucine zipper region of GCN4 were used for high-sensitivity microcalorimetric analysis. Each pair of mutants differed only by having alanine or...

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PMID: 8811731
DOI: 10.1002/(SICI)1097-0134(199606)25:2<143::AID-PROT1>3.0.CO;2-J

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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