Prediction of quaternary structure of coiled coils. Application to mutants of the GCN4 leucine zipper.

doi:10.1006/jmbi.1995.0447

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Article

Prediction of quaternary structure of coiled coils. Application to mutants of the GCN4 leucine zipper.

Journal of molecular biology - 18 Aug 1995

Vieth M, Kolinski A, Brooks C L, Skolnick J

Abstract excerpt

Using a simplified protein model, the equilibrium between different oligomeric species of the wild-type GCN4 leucine zipper and seven of its mutants have been predicted. Over the entire experimental concentration range, agreement with experiment is found in five cases, while in two cases agreemen...

Topics

Computer Simulation
DNA-Binding Proteins
Fungal Proteins
Hydrogen Bonding
Leucine Zippers
Monte Carlo Method
Mutation
Protein Conformation
Protein Folding
Protein Kinases
Saccharomyces cerevisiae Proteins
Thermodynamics

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