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Immortalization of normal human oral keratinocytes with type 16 human papillomavirus

1 Jan 1991

Abstract excerpt

Primary human oral keratinocytes were transformed by transfection with recombinant human papillomavirus type 16 (HPV-16) DNA, and two transformed cell lines named human oral keratinocytes-16A and -16B (HOK-16A and HOK-16B) were established. While normal cells and cells transfected with vector only exhibited a limited lifespan, the HOK-16A and HOK-16B lines demonstrated immortality and altered morphology from...

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PMID: 1654226
DOI: 10.1093/carcin/12.9.1627

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