Rapid diagnostic test for hereditary nonpolyposis colon cancer kindred using polymerase chain reaction.

doi:10.1007/BF02235383

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Article

Rapid diagnostic test for hereditary nonpolyposis colon cancer kindred using polymerase chain reaction.

Diseases of the colon and rectum - 1 Jul 1998

Faragher I G, Whitehead R H

Abstract excerpt

PURPOSE: We have identified a mutation in the hMLH1 gene from the proband of a hereditary nonpolyposis colorectal cancer kindred. We wished to develop a rapid test for this specific mutation to facilitate screening of other family members. METHOD: An allele-specific polymerase chain reaction stra...

Topics

Adaptor Proteins, Signal Transducing
Carrier Proteins
Colorectal Neoplasms, Hereditary Nonpolyposis
Genetic Carrier Screening
Genetic Testing
Humans
MutL Protein Homolog 1
Mutation
Neoplasm Proteins
Nuclear Proteins
Polymerase Chain Reaction

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