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Article

Rapid diagnostic test for hereditary nonpolyposis colon cancer kindred using polymerase chain reaction.

Diseases of the colon and rectum - 1 Jul 1998

Faragher I G, Whitehead R H

Abstract excerpt

PURPOSE: We have identified a mutation in the hMLH1 gene from the proband of a hereditary nonpolyposis colorectal cancer kindred. We wished to develop a rapid test for this specific mutation to facilitate screening of other family members. METHOD: An allele-specific polymerase chain reaction strategy was used to detect a T insertion at the + 3 splice site post exon 9 in the hMLH1 gene. The test was evaluated on...

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Identifiers

PMID: 9678385
DOI: 10.1007/BF02235383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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