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Article

Construction of a gyrA plasmid for genetic characterization of fluoroquinolone-resistant Staphylococcus aureus.

FEMS immunology and medical microbiology - 1 Jun 1994

Tankovic J, Duval J, Courvalin P

Abstract excerpt

We have constructed a gyrA trans-complementation plasmid, pAT512, by cloning the wild-type gyrA gene of Staphylococcus aureus into the expression vector pAT392. Introduction by electrotransformation of pAT512 into a high-level fluoroquinolone resistant mutant of S. aureus (ciprofloxacin MIC = 16 micrograms ml-1) having a gyrA mutation which results in a Ser-84 to Leu substitution, reduced the MICs of norfloxacin...

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Identifiers

PMID: 7920462
DOI: 10.1111/j.1574-695X.1994.tb00471.x

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