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Article

Amplification and Expression of Cyclin D Genes (<i>CCND1 CCND2 and CCND3</i>) in Human Malignant Gliomas

1 Jul 1999

Abstract excerpt

Malignant gliomas frequently show genetic aberrations of genes coding for cell cycle regulatory proteins involved in the control of G1/S phase transition. These include mutation and/or deletion of the retinoblastoma (RB1) gene, homozygous deletion of the CDKN2A and CDKN2B genes, as well as amplification and overexpression of the CDK4 and CDK6 genes. The D-type cyclins (cyclin D1, D2, and D3) promote cell cycle...

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Identifiers

PMID: 10416984
DOI: 10.1111/j.1750-3639.1999.tb00532.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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