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Article

p53-independent growth regulation of cervical cancer cells by the papillomavirus E6 oncogene.

Oncogene - 5 Sept 1996

Spitkovsky D, Aengeneyndt F, Braspenning J, von Knebel Doeberitz M

Abstract excerpt

Growth of cervical carcinoma cells depends on continuous expression of high risk type human papillomavirus oncogenes E6 and E7. E6 destabilizes p53, a tumor-suppressive transcription factor, which activates expression of the inhibitor of cell cycle progression p21 and other genes. E6-mediated p53 degradation can therefore result in cell cycle deregulation. It has, however, not yet been determined whether p53...

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PMID: 8806692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p53-independent growth regulation of cervical cancer cells by the papillomavirus E6 oncogene.PMID 8806692Read ↗

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