Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus.

doi:10.1038/347569a0

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Article

Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus.

Nature - 11 Oct 1990

Parry N, Fox G, Rowlands D, Brown F, Fry E, Acharya R, Logan D, Stuart D

Abstract excerpt

Changes resulting in altered antigenic properties of viruses nearly always occur on their surface and have been attributed to the substitution of residues directly involved in binding antibody. To investigate the mechanism of antigenic variation in foot-and-mouth disease virus (FMDV), variants th...

Topics

Antibodies, Monoclonal
Antigens, Viral
Aphthovirus
Capsid
Capsid Proteins
Disulfides
Enzyme-Linked Immunosorbent Assay
Epitopes
Genetic Variation
Molecular Structure
Protein Conformation
X-Ray Diffraction

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