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Article

Distinct mutations emerge in the genome of serotype O foot-and-mouth disease virus during persistence in cattle.

Journal of virology - 18 Mar 2025

Litz Benedikt, Forth Leonie F, Pfaff Florian, Beer Martin, Eschbaumer Michael

Abstract excerpt

Like other RNA viruses, foot-and-mouth disease virus (FMDV) has a high mutation rate. After the acute phase of infection, about half of infected cattle develop a persistent FMDV infection that can last for weeks or months. During this persistent phase, the virus continues to replicate, resulting in the emergence of genomic heterogeneity. We have documented the pattern of mutations in the persistent phase by...

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Identifiers

PMID: 39918330
DOI: 10.1128/jvi.01422-24
PMCID: PMC11915810

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