Article
Phenotypes of dnaA mutants of Escherichia coli sensitive to phenothiazine derivatives.
Molecular & general genetics : MGG - 27 Aug 1996
Mizushima T, Shinpuku T, Katayama H, Kataoka K, Guo L, Miki T, Sekimizu K
Abstract excerpt
The activation of DnaA protein by cardiolipin is inhibited by fluphenazine in vitro. We therefore examined the sensitivity of temperature-sensitive dnaA mutants of Escherichia coli to fluphenazine and other phenothiazine derivatives. Among the eight dnaA mutants tested, dnaA5, dnaA46 dnaA602, and dnaA604, mutants with mutations in the putative ATP binding site of DnaA protein, showed higher sensitivities to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.