Article
Resistance to trifluoroperazine, a calmodulin inhibitor, maps to the fabD locus in Escherichia coli.
Molecular & general genetics : MGG - 10 Mar 1995
Bouquin N, Tempête M, Holland I B, Séror S J
Abstract excerpt
A mutant, tfpA1, resistant to the calmodulin inhibitor trifluoroperazine (TFP) at 30 degrees C, was isolated in Escherichia coli. The mutant showed a reduced growth rate at 30 degrees C and was temperature sensitive (ts) at 42 degrees C for growth, forming short filaments. The mutation was mapped...
Topics
- Acyl-Carrier Protein S-Malonyltransferase
- Acyltransferases
- Bacterial Proteins
- Base Sequence
- Calmodulin
- Cell Membrane
- Chromosome Mapping
- Cloning, Molecular
- Drug Resistance, Microbial
- Escherichia coli
- Escherichia coli Proteins
- Fatty Acid Synthase, Type II
- Fatty Acids
- Genes, Bacterial
- Genetic Complementation Test
- Molecular Sequence Data
- Molecular Weight
- Mutation