Article
DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group system.
Vox sanguinis - 1 Jan 1996
Elmgren A, Börjeson C, Svensson L, Rydberg L, Larson G
Abstract excerpt
The human Lewis gene encodes an alpha(1,3/1,4)-fucosyltransferase responsible for synthesis of the Le(a) and a Le(b) antigens. To define the molecular background for non-functional Lewis genes we have sequenced PCR-amplified DNA fragments from two Le(a-b-) individuals. One was homozygously mutate...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Erythrocytes
- Genotype
- Humans
- Lewis Blood Group Antigens
- Molecular Sequence Data
- Nucleotide Mapping
- Pedigree
- Point Mutation
- Polymerase Chain Reaction
- White People