Article
Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII.
The Journal of biological chemistry - 29 Aug 1997
Elmgren A, Mollicone R, Costache M, Börjeson C, Oriol R, Harrington J, Larson G
Abstract excerpt
The Lewis alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII, encoded by the FUT3 gene is responsible for the final synthesis of Lea and Leb antigens. Various point mutations have been described explaining the Lewis negative phenotype, Le(a-b-), on erythrocytes and secretions. Two of these, T202C and C3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.