Article
Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees.
The Journal of biological chemistry - 19 Aug 1994
Mollicone R, Reguigne I, Kelly R J, Fletcher A, Watt J, Chatfield S, Aziz A, Cameron H S, Weston B W, Lowe J B
Abstract excerpt
The Le(a) and Le(b) human blood group antigens are synthesized in tissues producing exocrine secretions; they also circulate in plasma, where they are adsorbed by erythrocytes. They are synthesized by two fucosyltransferases, encoded by Lewis (FUT3) and secretor (FUT2) loci. This genetic model ha...
Topics
- Alleles
- Base Sequence
- Carbohydrate Sequence
- Cell Line
- Cells, Cultured
- Erythrocytes
- Female
- Fucosyltransferases
- Genotype
- Humans
- Indonesia
- Lewis Blood Group Antigens
- Male
- Molecular Sequence Data
- Mutation