Article
Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI family heart study.
Journal of internal medicine - 1 Jun 2000
Salomaa V, Pankow J, Heiss G, Cakir B, Eckfeldt J H, Ellison R C, Myers R H, Hiller K M, Brantley K R, Morris T L, Weston B W
Abstract excerpt
OBJECTIVES: To examine the prevalence of four mutations, T59G, T1067A, T202C and C314T, of the human alpha(1,3/1,4) fucosyltransferase 3 (FUT 3) gene amongst persons with Lewis negative and those with Lewis positive blood group phenotype. An additional objective was to explore the hypothesis that these mutations are associated with coronary heart disease and inflammatory reaction. DESIGN: A population-based...
Topics
- Arteriosclerosis
- Coronary Disease
- Cross-Sectional Studies
- DNA Primers
- Fucosyltransferases
- Gene Amplification
- Humans
- Lewis Blood Group Antigens
- Mutation
- Odds Ratio
- Phenotype