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Article

Genetic Variations of the FUT3 Gene in Le(a-b-) Individuals and Their Association with Lewis Antibody Responses.

Medical sciences (Basel, Switzerland) - 2 Oct 2025

Nathalang Oytip, Khumsuk Piyathida, Sasikarn Wiradee, Intharanut Kamphon

Abstract excerpt

Background: The biosynthesis of Lewis (Le) antigens depends on the FUT3 gene, encoding an α(1,3/4)-fucosyltransferase. Individuals lacking functional FUT3 exhibit a Le(a-b-) phenotype, regardless of secretor status. Methods: This study determined the prevalence of FUT3 single nucleotide variants (SNVs) in Thai blood donors and characterised genotype and allele distributions. We also examined the association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41133499
DOI: 10.3390/medsci13040218
PMCID: PMC12551007

Genes

FUT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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