Article
Investigation of genetic alterations associated with development and adverse outcome in patients with astrocytic tumor.
Journal of neuro-oncology - 1 Jun 2000
Cianciulli A M, Morace E, Coletta A M, Occhipinti E, Gandolfo G M, Leonardo G, Carapella C M
Abstract excerpt
Models describing progression in the genetic derangement of glial tumors have shown chromosomal loss and gain occurring most frequently in high-grade lesions, suggesting that identification of these aberrations may be prognostically significant. In this study, Fluorescence in situ hybridization (FISH) has been used to determine, and to confirm, loss and gain of chromosomes 1, 8, 10, 12 and 17, in formalin-fixed,...
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