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Article

Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells.

Journal of cellular physiology - 1 Mar 2007

Moffa Allison B, Ethier Stephen P

Abstract excerpt

Gene amplification and protein overexpression of fibroblast growth factor receptor 2 (FGFR2) characterize the SUM-52 breast cancer cell line developed in our laboratory. SUM-52 cells express nine distinct alternatively spliced isoforms of FGFR2. Among these isoforms are two otherwise identical FGFR2 variants that express either the C1 or C3 carboxyl terminus. FGFR2-C3 variants are not normally expressed by human...

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Share to Alternative Splicing
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Gene Expression Regulation, Neoplastic

Share to Mammary Glands, Human

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Share to Receptor, Fibroblast Growth Factor, Type 2

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Source

Identifiers

PMID: 17133345
DOI: 10.1002/jcp.20880

Genes

FGFR2
FRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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