Article
Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2.
Cancer research - 1 Aug 2015
Tanizaki Junko, Ercan Dalia, Capelletti Marzia, Dodge Michael, Xu Chunxiao, Bahcall Magda, Tricker Erin M, Butaney Mohit, Calles Antonio, Sholl Lynette M, Hammerman Peter S, Oxnard Geoffrey R, Wong Kwok-Kin, Jänne Pasi A
Abstract excerpt
The discovery of oncogenic driver mutations and the subsequent developments in targeted therapies have led to improved outcomes for subsets of lung cancer patients. The identification of additional oncogenic and drug-sensitive alterations may similarly lead to new therapeutic approaches for lung cancer. We identify and characterize novel FGFR2 extracellular domain insertion mutations and demonstrate that they are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.