Article
Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2012
Vets Sofie, Kimpel Janine, Volk Andreas, De Rijck Jan, Schrijvers Rik, Verbinnen Bert, Maes Wim, Von Laer Dorothee, Debyser Zeger, Gijsbers Rik
Abstract excerpt
Lens epithelium-derived growth factor (LEDGF/p75) is an essential cofactor of HIV integration. Both stable overexpression of the C-terminal part of LEDGF/p75 (LEDGF(325-530)) containing the integrase (IN)-binding domain (IBD) and stable knockdown (KD) of LEDGF/p75 are known to inhibit HIV infection in laboratory cell lines. Here, primary human CD(4)(+) T-cells were transduced with lentiviral vectors encoding...
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